Number of protein-coding genes
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| Value | 19042 Unitless |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Church et al, Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5 7(5):e1000112. abstract & p.2 right column 3rd paragraphPubMed ID19468303 |
| Method | "Using gene predictions for human and mouse from both NCBI [29] and Ensembl [30], [researchers] retained only those that were conserved either within or between the two species. Gene models were assessed for their reliability by: (i) comparing the exon boundaries in alignments of predicted orthologous and paralogous genes, (ii) considering whether mouse and human homologues lay within regions of conserved synteny, and (iii) automatically inspecting genes for reading frame disrupting mutations [31]."[Numbers point to refs in article] |
| Comments | "In a comprehensive analysis of this revised genome sequence, [researchers] are now able to define 20,210 protein-coding genes, over a thousand more than predicted in the human genome (19,042 genes)." "The availability of finished sequence for human, and now mouse, enables more-complete surveys of protein-coding genes in both species. [Researchers] now estimate that mouse and human reference genomes contain 20,210 and 19,042 protein-coding genes, respectively." For value of ~20,500 see BNID 100399. For 19,735 protein-coding genes in C. elegans see BNID 101364 |
| Entered by | Uri M |
| ID | 105447 |