Number of protein-coding genes
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| Value | 19042 Unitless |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Church et al, Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5 7(5):e1000112.PubMed ID19468303 |
| Method | Using gene predictions for human and mouse from both NCBI [29] and Ensembl [30], researchers retained only those that were conserved either within or between the two species. Gene models were assessed for their reliability by: (i) comparing the exon boundaries in alignments of predicted orthologous and paralogous genes, (ii) considering whether mouse and human homologues lay within regions of conserved synteny, and (iii) automatically inspecting genes for reading frame disrupting mutations [31]. [Numbers point to refs in free PMC Article]. |
| Comments | The process described in Measurement method section identified 20,210 high-quality protein-coding gene models in mouse and 19,042 such models in the human genome (Protocol S1, section: Protein Coding Genes and Gene Families). For value of 21,701 see BNID 100399 and for value of ~20,500 protein-coding genes see comments section therein. For 19,735 protein-coding genes in C. elegans see BNID 101364 |
| Entered by | Uri M |
| ID | 105447 |