| Value |
>=
%
Range: >90 %
|
| Organism |
Mouse Mus musculus |
| Reference |
Cheshier SH, Morrison SJ, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A. 1999 Mar 16 96(6):3120-5 abstract & p.3124 left column 3rd paragraphPubMed ID10077647
|
| Method |
Study of BrdUrd incorporation (Bromodeoxyuridine) kinetics |
| Comments |
Abstract: "BrdUrd incorporation was used to determine the rate at which different cohorts of HSC entered the cell cycle over time. About 50% of LT-HSC incorporated BrdUrd by 6 days and >90% incorporated BrdUrd by 30 days." P.3124 left column 3rd paragraph: "[Investigators] analyzed the in vivo proliferation and cell cycle kinetics of C57BL/Ka-Thy 1.1 mouse KTSL−/lo and KTSL− HSC. Over 90% of LT-HSC entered the cell cycle at least once every 30 days, and by 6 months >99% of LT-HSC divided. The subsets of cells analyzed in this experiment included all HSC in this mouse strain (ref 18)." |
| Entered by |
Paul Jorgensen |
| ID |
105230 |