Nucleotide misincorporation rate in transcription
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| Value | 1e-4 mismatch/nucleotide |
|---|---|
| Organism | Bacteria Escherichia coli |
| Reference | Hani S. Zaher and Rachel Green, Fidelity at the Molecular Level: Lessons from Protein Synthesis. Cell Volume 136, Issue 4, 20 February 2009, Pages 746-762PubMed ID19239893 |
| Primary Source | Rosenberger RF, Foskett G. An estimate of the frequency of in vivo transcriptional errors at a nonsense codon in Escherichia coli. Mol Gen Genet. 1981 183(3):561-3PubMed ID7038382 |
| Method | (Primary source ):The residual ß-galactosidase activity in strains carrying lacZ 2 or the same allele with a rho mutation indicate an RNA polymerase error rate of 1.4x10^-4. |
| Comments | This level of accuracy is lower than that of DNA replication and similar to that of translation. See BNID 105212 |
| Entered by | Uri M |
| ID | 103453 |