Difference in binding energy between distinct patches of contact between DNA and histones

Value 0.5 kcal/mol
Organism Eukaryotes
Reference Garcia HG, Grayson P, Han L, Inamdar M, Kondev J, Nelson PC, Phillips R, Widom J, Wiggins PA. Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers. 2007 Feb 585(2):115-30.PubMed ID17103419
Primary Source Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ. Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution.J Mol Biol. 2002 Jun 21319(5):1097-113PubMed ID12079350
Comments The interactions between protein and DNA within the nucleosome core particle can be divided into seven unique DNA-binding sites per half-particle, corresponding to the regions where the minor groove of the double helix faces inward (fig1(b) primary ref)
Entered by Uri M
ID 103142