Length of siRNA

Range 21-22 nucleotides
Organism Fruit fly Drosophila melanogaster
Reference Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 2001 Jan 1515(2):188-200.PubMed ID11157775
Primary Source Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000 Mar 31101(1):25-33.PubMed ID10778853
Method Drosophila in vitro system
Comments RNAi is ATP dependent yet uncoupled from mRNA translation.
Entered by Uri M
ID 102483