Mutation rate per genome per replication
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| Value | 0.16 mutation/genome/replication Range: Table - link mutation/genome/replication |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86 p.1673 table 5PubMed ID9560386 |
| Method | Calculated from 5×10^-11 mutation/base pair/replication taking genome size to be 3.2×10^9 base pairs. 5×10^-11mutations/base pair/replication×3.2×10^9base pairs/genome=0.16 mutation/genome/replication. Notice that this is per replication not per sexual generation |
| Comments | Table 5 also gives: 1)Mutation rate per effective genome per replication, calculated thus: Taking 8×10^7 bases as effective genome (portion of genome in which mutations are deleterious): 8×10^7×5×10^-11=0.004mutations per effective genome per replication. 2)Mutation rate per effective genome per sexual generation calculated by assuming that overwhelming majority of mutations take place in males and that number of divisions prior to sperm formation in male of age 30 is 400: 0.004mutation/base pair/replication×400replications/generation=1.6 mutations/effective genome/sexual generation. See BNID 104752, 100414 |
| Entered by | Ron Milo - Admin |
| ID | 100417 |